01 / GENERATE
Protein Generation
Reasoning models define design constraints to guide sequence and structural backbone generation.
FUNCTION-FIRST PROTEIN DESIGN
Reason to Define Function.
Generate to Realize Design.
Therapeutic proteins, designed on demand.
From AI4Math and AI4Code to AI4Science,
AI is moving from solving problems and writing code to scientific discovery.
01 / LEXIFORGE CLOSED-LOOP INTELLIGENCE
LexiForge: Our Solution
02 / EVALUATE
Function Prediction
Predict de novo protein function. Optimize developability and immunogenicity.
03 / LEARN
Active Learning
Wet-lab data continually calibrates models and informs the next design cycle.
LEXIFORGE
CLOSED LOOP
02 / VALIDATION & SERVICES
Validated Design. Ready for Your Next Discovery.
Designed proteins bind their targets
Designed proteins are expressed
Up to 100% miniprotein expression;
over 90% for nanobodies
Best binding affinity
>10% achieve single-digit nanomolar affinity
CASE STUDY
IFNAR2 VHH Binder
44% Hit rateCASE STUDY
PD-L1 Binder
82.9% Hit rateBest Binder <1 nM Kd
03 / OUR SERVICES
Bring Validated Capabilities to Your Research.
01 / DE NOVO BINDER DESIGN
De Novo Protein Design
Design sequences from scratch for a specified target protein and site, generating candidates with the desired binding capability.
VHH / scFv / Antibody / Miniprotein
02 / AFFINITY ENGINEERING
Affinity Engineering
Use computational design and sequence optimization to increase or decrease the binding affinity of an existing protein.
Existing sequence → Tuned affinity
PARTNERSHIPS & INVESTMENT
Bring your next design challenge
to Lexicodon.
04 / OUR NAME
Lexicodon Therapeutics
Lexicodon brings together lexico, the idea of language, and codon, a unit of genetic information. The name connects the language we use to understand the world with the molecular sequences through which cells read genetic information.
The Language of Life.
05 / CAREERS
Join us to shape the future of AI for Biology.
OPEN ROLE
AI Protein Design Engineer
Send your CV and a brief project introduction to: careers@lexicodon.com